The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function-Reference-Cited by-同舟云学术

The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function

Published:2021-08-26 Issue:12 Volume:402 Page:1591-1596
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Subramanyam Sudheendra Hebbar¹,Tenbrock Klaus¹²³^ORCID

Affiliation:

1. Department of Pediatrics , Pediatric Pneumology, Allergology and Immunology, RWTH Aachen University , Aachen , Germany

2. Interdisciplinary Center for Clinical Research IZKF , Aachen , Germany

3. Interdisciplinary Center for Clinical Research IZKF , Münster , Germany

Abstract

Abstract The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4+ T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4+ T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2021-0249/pdf

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