Role of the gut microbiota in airway immunity and host defense against respiratory infections
Author:
Willers Maike1ORCID, Viemann Dorothee123
Affiliation:
1. Department of Pediatric Pneumology, Allergology and Neonatology , Hannover Medical School , D-30625 Hannover , Germany 2. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School , D-30625 Hannover , Germany 3. Department of Pediatrics , Translational Pediatrics, University Hospital Würzburg , Zinklesweg 10 , D-97078 Würzburg , Germany
Abstract
Abstract
Colonization of the intestine with commensal bacteria is known to play a major role in the maintenance of human health. An altered gut microbiome is associated with various ensuing diseases including respiratory diseases. Here, we summarize current knowledge on the impact of the gut microbiota on airway immunity with a focus on consequences for the host defense against respiratory infections. Specific gut commensal microbiota compositions and functions are depicted that mediate protection against respiratory infections with bacterial and viral pathogens. Lastly, we highlight factors that have imprinting effects on the establishment of the gut microbiota early in life and are potentially relevant in the context of respiratory infections. Deepening our understanding of these relationships will allow to exploit the knowledge on how gut microbiome maturation needs to be modulated to ensure lifelong enhanced resistance towards respiratory infections.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Reference114 articles.
1. Abrahamsson, T.R., Jakobsson, H.E., Andersson, A.F., Björkstén, B., Engstrand, L., and Jenmalm, M.C. (2014). Low gut microbiota diversity in early infancy precedes asthma at school age. Clin. Exp. Allergy 44: 842–850, https://doi.org/10.1111/cea.12253. 2. Abt, M.C., Osborne, L.C., Monticelli, L.A., Doering, T.A., Alenghat, T., Sonnenberg, G.F., Paley, M.A., Antenus, M., Williams, K.L., Erikson, J., et al.. (2012). Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37: 158–170, https://doi.org/10.1016/j.immuni.2012.04.011. 3. Ang, Q.Y., Alexander, M., Newman, J.C., Tian, Y., Cai, J., Upadhyay, V., Turnbaugh, J.A., Verdin, E., Hall, K.D., Leibel, R.L., et al.. (2020). Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells. Cell 181: 1263–1275.e16, https://doi.org/10.1016/j.cell.2020.04.027. 4. Antunes, K.H., Fachi, J.L., de Paula, R., da Silva, E.F., Pral, L.P., Dos Santos, A.Á., Dias, G.B.M., Vargas, J.E., Puga, R., Mayer, F.Q., et al.. (2019). Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat. Commun. 10: 3273, https://doi.org/10.1038/s41467-019-11152-6. 5. Arboleya, S., Sánchez, B., Milani, C., Duranti, S., Solís, G., Fernández, N., de los Reyes-Gavilán, C.G., Ventura, M., Margolles, A., and Gueimonde, M. (2015). Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics. J. Pediatr. 166: 538–544, https://doi.org/10.1016/j.jpeds.2014.09.041.
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