Chemically modified glycosaminoglycan derivatives as building blocks for biomaterial coatings and hydrogels

Author:

Schnabelrauch Matthias1ORCID,Schiller Jürgen2ORCID,Möller Stephanie1ORCID,Scharnweber Dieter3ORCID,Hintze Vera3ORCID

Affiliation:

1. Biomaterials Department , INNOVENT e.V. , Prüssingstrasse 27B, D-07745 Jena , Germany

2. Institute for Medical Physics and Biophysics, Medical Faculty, Universität Leipzig , D-04107 Leipzig , Germany

3. Institute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden , Budapester Str. 27, D-01069 Dresden , Germany

Abstract

Abstract Tissue regeneration is regulated by the cellular microenvironment, e.g. the extracellular matrix. Here, sulfated glycosaminoglycans (GAG), are of vital importance interacting with mediator proteins and influencing their biological activity. Hence, they are promising candidates for controlling tissue regeneration. This review addresses recent achievements regarding chemically modified GAG as well as collagen/GAG-based coatings and hydrogels including (i) chemical functionalization strategies for native GAG, (ii) GAG-based biomaterial strategies for controlling cellular responses, (iii) (bio)chemical methods for characterization and iv) protein interaction profiles and attained tissue regeneration in vitro and in vivo. The potential of GAG for bioinspired, functional biomaterials is highlighted.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

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