Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers
Author:
Milton Anna V.1ORCID, Konrad David B.1ORCID
Affiliation:
1. Department of Pharmacy , Ludwig Maximilian University of Munich , Butenandtstr. 5-13, Haus C, D-81377 Munich , Germany
Abstract
Abstract
Mutation-selective drugs constitute a great advancement in personalized anticancer treatment with increased quality of life and overall survival in cancers. However, the high adaptability and evasiveness of cancers can lead to disease progression and the development of drug resistance, which cause recurrence and metastasis. A common characteristic in advanced neoplastic cancers is the epithelial-mesenchymal transition (EMT) which is strongly interconnected with H2O2 signaling, increased motility and invasiveness. H2O2 relays its signal through the installation of oxidative posttranslational modifications on cysteines. The increased H2O2 levels that are associated with an EMT confer a heightened sensitivity towards the induction of ferroptosis as a recently discovered vulnerability.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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