The paracaspase MALT1 in psoriasis-Reference-Cited by-同舟云学术

The paracaspase MALT1 in psoriasis

Published:2021-07-01 Issue:12 Volume:402 Page:1583-1589
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Hailfinger Stephan¹^ORCID,Schulze-Osthoff Klaus²³⁴

Affiliation:

1. Department of Medicine A, Hematology, Oncology and Pneumology , University Hospital Münster , Domagkstr. 3 , D-48149 Münster , Germany

2. Interfaculty Institute of Biochemistry , University of Tübingen , D-72076 Tübingen , Germany

3. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) , D-69120 Heidelberg , Germany

4. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies” , University of Tübingen , D-72076 Tübingen , Germany

Abstract

Abstract Psoriasis is a frequent autoimmune-related skin disease, which involves various cell types such as T cells, keratinocytes and dendritic cells. Genetic variations, such as mutations of CARD14, can promote the development of the disease. CARD14 mutations as well as the stimulation of immune and cytokine receptors activate the paracaspase MALT1, a potent activator of the transcription factors NF-κB and AP-1. The disease-promoting role of MALT1 for psoriasis is mediated by both its protease activity as well as its molecular scaffold function. Here, we review the importance of MALT1-mediated signaling and its therapeutic implications in psoriasis.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2021-0250/pdf

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