Synthesis and application of nanometer hydroxyapatite in biomedicine-Reference-Cited by-同舟云学术

Synthesis and application of nanometer hydroxyapatite in biomedicine

Published:2022-01-01 Issue:1 Volume:11 Page:2154-2168
ISSN:2191-9097
Container-title:Nanotechnology Reviews
language:en
Short-container-title:

Author:

Gui Xingyu¹²,Peng Wei³,Xu Xiujuan¹²,Su Zixuan¹²,Liu Gang⁴,Zhou Zhigang⁴,Liu Ming⁴,Li Zhao³,Song Geyang³,Zhou Changchun¹²,Kong Qingquan⁴

Affiliation:

1. College of Biomedical Engineering, Sichuan University , Chengdu 610064 , China

2. National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064 , China

3. West China School of Public Health and West China Fourth Hospital, Sichuan University , Chengdu 610041 , China

4. Department of Orthopedics, West China Hospital, Sichuan University , 610041, Chengdu , China

Abstract

Abstract Nano-hydroxyapatite (nano-HA) has been widely studied as a promising biomaterial because of its potential mechanical and biological properties. In this article, different synthesis methods for nano-HA were summarized. Key factors for the synthesis of nano-HA, including reactant concentration, effects of temperature, PH, additives, aging time, and sintering, were separately investigated. The biological performances of the nano-HA depend strongly on its structures, morphology, and crystallite sizes. Nano-HA with different morphologies may cause different biological effects, such as protein adsorption, cell viability and proliferation, angiogenesis, and vascularization. Recent research progress with respect to the biological functions of the nano-HA in some specific biological applications are summarized and the future development of nano-sized hydroxyapatite is prospected.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/ntrev-2022-0127/pdf

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