Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery-Reference-Cited by-同舟云学术

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Published:2018-06-02 Issue:4 Volume:7 Page:291-301
ISSN:2191-9097
Container-title:Nanotechnology Reviews
language:en
Short-container-title:

Author:

Jiao Zepeng¹,Zhang Bin²,Li Chunya²,Kuang Weicong²,Zhang Jingxian²,Xiong Yongqiang²,Tan Shaozao²,Cai Xiang³,Huang Langhuan²

Affiliation:

1. Analysis and Test Center , Jinan University , Guangzhou 510632 , P.R. China

2. Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products , Department of Chemistry , Jinan University , Guangzhou 510632 , P.R. China

3. Department of Light Chemical Engineering , Guangdong Polytechnic , Foshan 528041 , P.R. China

Abstract

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

Reference38 articles.

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J. Clin. 2017, 67, 7–30.

2. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017, 66, 683–691.

3. Barreto JA, O’Malley W, Kubeil M, Graham B, Stephan H, Spiccia L. Nanomaterials: applications in cancer imaging and therapy. Adv. Mater. 2011, 23, H18–H40.

4. Sanna V, Pala N, Sechi M. Targeted therapy using nanotechnology: focus on cancer. Int. J. Nanomed. 2014, 9, 467–483.

5. Bahrami B, Hojjat-Farsangi M, Mohammadi H, Anvari E, Ghalamfarsa G, Yousefi M, Jadidi-Niaragh F. Nanoparticles and targeted drug delivery in cancer therapy. Immunol. Lett. 2017, 190(Supplement C), 64–83.

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