Hydrogel based 3D carriers in the application of stem cell therapy by direct injection

Author:

Luan Chengxin1,Liu Ping1,Chen Runzhe1,Chen Baoan2

Affiliation:

1. Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China

2. Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, Jiangsu Province, P.R. China

Abstract

AbstractCompared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment rate still need to be overcome before its application in humans. Stem cell therapy supported by hydrogel carriers has been increasingly studied in recent years. These hydrogels with properties similar to natural tissues are able to fabricate various forms of carriers, which include in situ forming hydrogels, ex situ forming hydrogels, surface immobilization carriers, microencapsules, and microgels. Some of them are 3D carriers and promise to overcome the technical barriers of stem cell therapy by direct injection. They have different characteristics, application, and prospect in the application of stem cell therapy by direct injection, which is summarized by this review.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

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