New generation of oxide-based nanoparticles for the applications in early cancer detection and diagnostics
Author:
Godlewski Michal M.12, Kaszewski Jaroslaw123, Kielbik Paula12, Olszewski Jaroslaw2, Lipinski Waldemar2, Slonska-Zielonka Anna12, Rosowska Julita3, Witkowski Bartlomiej S.3, Gralak Mikolaj A.1, Gajewski Zdzislaw2, Godlewski Marek3
Affiliation:
1. Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW , Nowoursynowska 159, 02-776 Warsaw , Poland 2. Veterinary Research Centre/Centre for Biomedical Research, Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW , Nowoursynowska 100, 02-797 Warsaw , Poland 3. Institute of Physics, Polish Academy of Sciences , Al. Lotnikow 32/46, 02-668 Warsaw , Poland
Abstract
Abstract
Hereby the possible applications of oxide nanoparticles in the cancer diagnostics and therapy are presented. Cancer diseases are nowadays one of the most common causes of death in the highly-developed countries. Discussed will be the current clinical cancer detection methods with their shortcomings. The role of nanomedicine in cancer medicine and the potential applications of nanoparticles debated in the literature will be critically evaluated. In the second part, the most common methods for the nanoparticle synthesis will be discussed. Finally, the system for cancer detection based on the enhanced permeation-retention of multimodal high-k oxide nanoparticles doped with lanthanides will be proposed for both for themagnetic resonance imaging (non-gadolinium contrast agents) and for fluorescence guided biopsy and surgery.
Publisher
Walter de Gruyter GmbH
Subject
Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology
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