Cytotoxic Properties of Oligostilbenoids from the Tree Barks of Hopea dryobalanoides

Author:

Sahidin 1,Hakim Euis H.1,Juliawaty Lia D.2,Syah Yana M.1,Din Laily bin3,Ghisalberti Emilio L.4,Latip Jalifah3,Said Ikram M.3,Achmad Sjamsul A.2

Affiliation:

1. Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

2. Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia

3. School of Chemistry and Food Technology, Faculty of Science and Technology, National University of Malaysia, 43600 Bangi, Selangor, Malaysia

4. Chemistry, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA 6909, Australia

Abstract

Abstract A new modified stilbene dimer, diptoindonesin D (1), was isolated from the acetone extract of the tree bark of Hopea dryobalanoides, together with seven known compounds, parviflorol (2), (D)-balanocarpol (3), heimiol A (4), hopeafuran (5), (+)-α-viniferin (6), vaticanol B (7) and (D)-hopeaphenol (8). Cytotoxic properties of compounds 1-8 were evaluated against murine leukemia P-388 cells. Compound 8 was found to be the most active with IC50 of 5.7 μm

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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