XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines

Author:

Legaspi Enrico Daniel R.12,Sitchon Ma. Stefany Daennielle G.13,Jacinto Sonia D.3,Basilia Blessie A.4,Martinez Imee Su12

Affiliation:

1. Institute of Chemistry, College of Science , University of the Philippines Diliman , Quezon City , Metro Manila 1101 , Philippines

2. Natural Sciences Research Institute , University of the Philippines Diliman , Quezon City , Metro Manila 1101 , Philippines

3. Institute of Biology, College of Science , University of the Philippines Diliman , Quezon City , Metro Manila 1101 , Philippines

4. Department of Science and Technology , Materials Science Division, Industrial Technology Development Institute , Taguig City , Metro Manila 1631 , Philippines

Abstract

Abstract Distinct properties that nanomaterials possess compared to their bulk counterparts are attributed to their characteristic high surface area to volume ratios, and the prevalence of structure and shape effects at the nanoscale. However, these interesting properties are also accompanied by health hazards that are not seen in bulk materials. In the context of Philippine research and industry, the issue of nanosafety and the creation of nanotechnology guidelines have long been overlooked. This is of particular importance considering that nanotechnology research in the Philippines leans heavily towards medicinal and agricultural applications. In this study, nanomaterial samples from the industry submitted through the Philippine Industrial Technology Development Institute (ITDI) were analyzed using XRD and MTT cytotoxicity assay. XRD results show significant band broadening in the diffraction patterns of halloysite nanoclay, bentonite nanoparticles, silver nanoparticles, and CaCO3 nanoparticles, indicating that samples were in the nanometer range. The diffraction pattern of TiO2, however, did not exhibit band broadening, which may be due to the tendency of TiO2 nanoparticles to aggregate. Submitted samples were also assessed for their effect on cell viability using MTT cytotoxicity assay. Among these samples, only silver nanoparticles exhibited cytotoxicity to the AA8 cell line.

Funder

Republic of the Philippines Department of Science of Science and Technology-Philippine Council for Industry, Energy, and Emerging Technology Research and Development

Natural Sciences Research Institute

Publisher

Walter de Gruyter GmbH

Subject

General Physics and Astronomy,General Materials Science,General Chemistry

Reference32 articles.

1. Furxhi, I. Health and environmental safety of nanomaterials: O data, where art thou? NanoImpact 2022;25:1–13. https://doi.org/10.1016/j.impact.2021.100378.

2. Important issues on risk assessment of manufactured nanomaterials. Paris: Organisation for Economic Co-operation and Development Environment Directorate Chemicals and Biotechnology Committee; 2022. Available from: https://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV-CBC-MONO(2022)3%20&doclanguage=en [Accessed 14 Jan 2023].

3. Sahu, D, Kannan, GM, Tailang, M, Vijayaraghavan, R. In vitro cytotoxicity of nanoparticles: a comparison between particle size and cell type. J Nanosci 2016;2016:1–9. https://doi.org/10.1155/2016/4023852.

4. Ashraf, MA, Peng, W, Zare, Y, Rhee, KY. Effects of size and aggregation/agglomeration of nanoparticles on the interfacial/interphase properties and tensile strength of polymer nanocomposites. Nanoscale Res Lett 2018;13:1–7. https://doi.org/10.1186/s11671-018-2624-0.

5. Formulation of roadmap and sectoral plan for five emerging technologies: Advanced materials and nanotechnology. Taguig: DOST PCIEERD; 2020. Available from: https://pcieerd.dost.gov.ph/images/pdf/2021/roadmaps/Advanced%20Materials%20and%20Nanotechnology%20Strategy%20Paper%20v7.3.pdf [Accessed 14 Jan 2023].

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