Treatment of denture stomatitis using iron nanoparticles green-synthesized by Silybum marianum extract

Abstract

Abstract Stomatitis or generalized inflammation of the mouth includes inflammation or pain in the mouth. Natural compounds are one of the best options for stomatitis treatment. Silybum marianum has many medicinal properties in traditional medicine. In recent research, iron nanoparticles were formulated by S. marianum. The research aim was to determine the Fe nanoparticles’ (FeNPs) efficacy in denture stomatitis treatment. FeNPs were characterized by TEM, FE-SEM, and UV-Visible. This was a clinical trial study with 60 patients who received FeNPs. The patients in 14 days were suggested to use mouthwash 1 time per 6 h each time 15–20 drops for 120–180 s and after that they should avoid drinking and eating for 0.5 h; patients in the two groups were offered to apply the drug. At each visit, mycological samples were taken for culture from the palatal mucosa. Inflammation amount and erythema were determined in each session and determined with a graded blade and recorded. The erythema surface of the palatal was significantly decreased in the group at follow-up visits compared to the pretreatment condition.