Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study-Reference-Cited by-同舟云学术

Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study

Published:2023-01-01 Issue:1 Volume:21 Page:
ISSN:2391-5420
Container-title:Open Chemistry
language:en
Short-container-title:

Author:

Mubaraki Murad A.¹,Almuayrifi Hussain A.¹,Hafiz Taghreed A.¹,Alyousef Abdulaziz¹,Dkhil Mohamed A.²,Thagfan Felwa A.³,Abdel-Gaber Rewaida⁴,Al-Najjar Mohammad A. A.⁵,Alkhudhayri Abdulsalam⁶,Elshanat Sherif⁷

Affiliation:

1. Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University , Riyadh , 12372 , Saudi Arabia

2. Department of Zoology and Entomology, Faculty of Sciences, Helwan University , Cairo , Egypt

3. Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University , Riyadh , Saudi Arabia

4. Department of Zoology, Faculty of Science, Cairo University , Giza , Egypt

5. Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University , Amman , Jordan

6. Department of Biology, College of Science, University of Hafr Al Batin , Hafr Al Batin , Saudi Arabia

7. Department of Parasitology, Faculty of Veterinary Medicine, Alexandria University , Alexandria , Egypt

Abstract

Abstract This study aimed to evaluate the prevalence and trends of transfusion-transmitted infections (TTIs) in two hospitals in Riyadh, as well as to judge the best type of tests to ensure blood transfusion safety. By using serological and nucleic acid test (NAT) tests, these donors were screened for human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), human T-lymphotropic virus type 1 (HTLV-1), human T-lymphotropic virus type 2 (HTLV-2), syphilis, and malaria infection as a first time of donation. Out of 58,898 blood units, 336 units were reacted for HBsAg, 5,318 units for HBcAbs, 506 units for HCV antibodies, 214 units for HIV Ab/Ag combinations, 206 units for HTLV antibodies, 355 units for syphilis antibodies, and 81 units for malaria. Moreover, the genotypic prevalence of these products showed that 349 units reacted for HBV DNA, HCV RNA, and HIV RNA in blood donation. This study reflects the seriousness of the residual risk of TTI, which is still a threat factor for the transmission of blood-borne infectious diseases. It was discovered that utilising (NAT) could increase test sensitivities while also lowering residual TTI risks, improving blood safety, and being cost-effective.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/chem-2022-0351/pdf

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