Phytochemical analysis and anticancer activity of the <i>Pithecellobium dulce</i> seed extract in colorectal cancer cells-Reference-Cited by-同舟云学术

Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells

Published:2023-01-01 Issue:1 Volume:21 Page:
ISSN:2391-5420
Container-title:Open Chemistry
language:en
Short-container-title:

Author:

Alhamed Abdullah S.¹,Alqinyah Mohammed¹,Alghaith Adel F.²,Algahtani Mohammad M.¹,Alqahtani Faleh¹,Nasr Fahd A.³,Alqahtani Ali S.³,Noman Omar M.³,Bazaid Abdulrahman S.⁴,AlMalki Reem Hussain⁵⁶,Abdel Rahman Anas M.⁶⁷,Alhazzani Khalid¹,Alanazi Ahmed Z.¹

Affiliation:

1. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia

2. Department of Pharmaceutics, College of Pharmacy, King Saud University , P.O. Box 2457 , Riyadh 11451 , Saudi Arabia

3. Department of Pharmacognosy, College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia

4. Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Hail , Hail , Saudi Arabia

5. Department of Botany and Microbiology, College of Science, King Saud University , Riyadh 11451 , Saudi Arabia

6. Metabolomics Section, Department of Clinical Genomics, Center for Genomics Medicine, King Faisal Specialist Hospital and Research Centre (KFSHRC) , Riyadh 11211 , Saudi Arabia

7. Department of Biochemistry and Molecular Medicine, College of Medicine, Al Faisal University , Riyadh 11533 , Saudi Arabia

Abstract

Abstract Colorectal cancer remains a challenging medical issue worldwide, and utilizing natural products and plants to produce novel, effective and safe therapies against this disease is continuously a sought-after strategy. Fruit and leaf extracts of Pithecellobium dulce (P. dulce) showed potential anticancer properties as they induced apoptosis of breast cancer and Dalton’s lymphoma ascites cells. Thus, the main objective of the current study is to determine whether the seed extract of P. dulce will affect apoptosis, cell cycle, migration, and inflammation of LoVo colorectal cancer cells. The high-resolution liquid chromatography–mass spectrometry was used to determine the chemical composition of the P. dulce seed extract, which revealed the presence of 35 phytochemicals. The findings of this study indicated a significant cytotoxic effect of seeds of this plant in colorectal cancer characterized by induction of apoptosis, cell cycle arrest, and reduction of migration. In addition, the seed extract suppressed several genes that are essential for cancer progression such as MMP2, MMP9, and IL-8, and, on the other hand, upregulated pro-apoptotic genes such as BAX and P53. This study has established P. dulce as a potential and valuable source for providing future therapies against colorectal cancer and other cancers.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/chem-2023-0362/pdf

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