Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model

Author:

Kocabas Rahim1,Yarkac Fatma Ucan2,Karabulut Ercan3,Keles Mert4

Affiliation:

1. Department of Biochemistry, Faculty of Medicine, Karamanoğlu Mehmetbey University , Karaman , Turkey

2. Faculty of Medicine, Faculty of Dentistry, Necmettin Erbakan University , Konya , Turkey

3. Department of Medical Pharmacology, Faculty of Medicine, Ankara Yıldırım Beyazıt University , Ankara , Turkey

4. Faculty of Medicine, Faculty of Dentistry, Lokman Hekim University , Ankara , Turkey

Abstract

Abstract Periodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4–5 months old with a body weight of 275 ± 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

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