Ducrosia ismaelis Asch. essential oil: chemical composition profile and anticancer, antimicrobial and antioxidant potential assessment

Author:

Mothana Ramzi A.1,Nasr Fahd A.2,Khaled Jamal M.3,Noman Omar M.2,Abutaha Nael4,Al-Rehaily Adnan J.1,Almarfadi Omar M.1,Kurkcuoglu Mine5

Affiliation:

1. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh11451, Saudi Arabia

2. Medicinal Aromatic, and Poisonous Plants Research Centre, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh11451, Saudi Arabia

3. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh11451, Saudi Arabia

4. Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

5. Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey

Abstract

AbstractThe essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty constituents were characterized, representing 96.1% of the total oil. The D. ismaelis essential oil (DIEO) was distinguished by a high composition of oxygenated monoterpenes (51.6%). Decanal (40.6%), α-pinene (15.1%) and dodecanal (13.7%) were the fundamental components. Additionally, DIEO was evaluated for its cytotoxic, antibacterial, antifungal and antioxidant activities. DIEO revealed a great cytotoxic effectiveness against the tested cancer cell lines with IC50 values between 66.2 and 137.3 μg/mL particularly against MCF-7 cancer cells. Furthermore, the induction of apoptosis against MCF-7 cells has been asserted using staining assay (annexin VFITC and/or propidium iodide (PI) dyes) and flow cytometry technique. The DIEO possessed a strong antimicrobial activity against Gram-positive bacterial and fungal strains with MIC-values between 0.07 and 0.31 mg/ml. The values of MBC or MFC were almost once higher than those of MIC’s. Moreover, the β-carotene-bleaching and DPPH free radical-scavenging tests showed that DIEO had a moderate activity (68%) as an antioxidant agent in decolouring of the β-carotene at 1.0 mg/mL and a moderate radical scavenging for DPPH (66 and 72%) at 0.50 and 1.0 mg/mL.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

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