Trimester-specific reference intervals for haemoglobin A1c (HbA1c) in pregnancy

Abstract

AbstractDiabetes in pregnancy imposes additional risks to both mother and infant. These increased risks are considered to be primarily related to glycaemic control which is monitored by means of glycated haemoglobin (HbAThe authors recruited 311 non-diabetic Caucasian pregnant (n=246) and non-pregnant women (n=65). A selective screening based on risk factors for gestational diabetes was employed. All subjects had a random plasma glucose <7.7 mmol/L and normal haemoglobin level. Pregnancy trimester was defined as trimester 1 (T1, n=40) up to 12 weeks +6 days, trimester 2 (T2, n=106) 13–27 weeks +6 days, trimester 3 (T3, n=100) >28 weeks to term.The normal HbAHbA