Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children

Abstract

AbstractAsthma is an airway disorder characterized by bronchial inflammation. An imbalance between the oxidative forces and the antioxidant defense systems has been implicated in the pathogenesis of asthma. Glutathione S-transferases (GSTs) play an important role in cellular protection against inflammation. Several studies have investigated the genetic variability of GSTM1, GSTP1 and GSTT1 enzymes in asthma development with conflicting results. Moreover, in our previous independent case-control study on GSTs and asthma, we have found thatIn this study, we performed an association study on 127 asthmatic children and 126 controls. We screened single nucleotide polymorphisms atTheConfirming our previous study, these findings suggest that the