1. Department of Anesthesiology Intensive Care and Pain Treatment, University of L’Aquila , Località Coppito, Piazzale Salvatore Tommasi, 1-67100 , L’Aquila , Italy
2. Department of Oncology and Hematology, Humanitas Clinical and Research Center , 20089 Rozzano (Milan) , Italy
3. Department of Oncology, San Giovanni-Addolorata Hospital , 00184 , Rome , Italy