Second trimester fetal thymus size in association to preterm birth-Reference-Cited by-同舟云学术

Second trimester fetal thymus size in association to preterm birth

Published:2021-10-27 Issue:2 Volume:50 Page:144-149
ISSN:0300-5577
Container-title:Journal of Perinatal Medicine
language:en
Short-container-title:

Author:

Porschen Christian¹,Schmitz Ralf¹,Schmidt Rene²,Oelmeier Kathrin¹,Hammer Kerstin¹,Falkenberg Maria¹,Braun Janina¹,Köster Helen Ann¹,Steinhard Johannes³,Möllers Mareike¹

Affiliation:

1. Department of Gynecology and Obstetrics , University Hospital Münster , Munster , Germany

2. Institute of Biostatistics and Clinical Research, University of Münster , Munster , Germany

3. Fetal Cardiology, Heart and Diabetes Center NRW, Ruhr-University Bochum , Bad Oeynhausen , Germany

Abstract

Abstract Objectives The aim of this study was to compare the second trimester thymus-thorax-ratio (TTR) between fetuses born preterm (study group) and those born after 37 weeks of gestation were completed (control group). Methods This study was conducted as a retrospective evaluation of the ultrasound images of 492 fetuses in the three vessel view. The TTR was defined as the quotient of a.p. thymus diameter and a.p. thoracic diameter. Results Fetuses that were preterm showed larger TTR (p<0.001) the second trimester than those born after 37 weeks of gestation were completed. The sensitivity of a binary classifier based on TTR for predicting preterm birth (PTB) was 0.792 and the specificity 0.552. Conclusions In our study, fetuses affected by PTB showed enlarged thymus size. These findings led us to hypothesize, that inflammation and immunomodulatory processes are altered early in pregnancies affected by PTB. However, TTR alone is not able to predict PTB.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpm-2021-0065/pdf

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