CB2 receptor agonist JWH133 activates AMPK to inhibit growth of C6 glioma cells-Reference-Cited by-同舟云学术

CB2 receptor agonist JWH133 activates AMPK to inhibit growth of C6 glioma cells

Published:2019-07-22 Issue:1 Volume:14 Page:363-375
ISSN:2391-5412
Container-title:Open Life Sciences
language:
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Author:

Wang Feng¹,Wang Jing²,Zhao Tong³,Zhang Yi³,Li Qian³¹

Affiliation:

1. Department of Physiology, Hebei Medical University, Shijiazhuang050017, China

2. Hebei Provincial Cancer Institute, Shijiazhuang050011, China

3. Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang050000, China

Abstract

AbstractIt has been reported that endocannabinoid receptor type 2 (CB2) agonist JWH133 inhibits the growth of C6 glioma cells, but the underlying mechanism has not yet been fully elucidated. We showed that JWH133 inhibited C6 cells growth, reduced cAMP production and inhibited PKA activity through CB2 receptor. Decrease of PKA activity stimulated CaMKKβ, and subsequently elevated phosphorylation of AMPKα at threonine 172 site. The activation of AMPKα induced changes of downstream proteins, including increase of P53 phosphorylation and P21 production, as well as decrease of mTOR phosphorylation, that eventually inhibited C6 cells growth.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/downloadpdf/journals/biol/14/1/article-p363.xml

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