Effects of Huaiqihuang Granules adjuvant therapy in children with primary nephrotic syndrome-Reference-Cited by-同舟云学术

Effects of Huaiqihuang Granules adjuvant therapy in children with primary nephrotic syndrome

Published:2019-12-31 Issue:1 Volume:14 Page:519-527
ISSN:2391-5412
Container-title:Open Life Sciences
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Author:

Zhou Ping¹,Xiao Qiong²,Chen Lan¹,Zou Zhi-Jie¹,Wang Yu-Qing¹,Zhu Lin¹,Yu Hai-Yan¹,Zhao Cheng-Guang³,Wu Yu-Bin³,Du Xuan-Yi⁴

Affiliation:

1. Department of pediatrics, 2nd Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang province, 150086,China

2. Department of Infections Diseases, Children's Hospital of Harbin,Harbin city, Heilongjiang province, 150010,China

3. Pediatric kidney rheumatology, Shengjing Hospital Affiliated of China Medical University, Shenyang, 110004, China

4. Department of Nephrology, 2nd Affiliated Hospital of Harbin Medical University, No.246 of Xuefu street, Nangang District, Harbin, 150086, China

Abstract

AbstractObjectiveThis study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS).MethodsA total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and immunoglobulin were observed.ResultsBefore treatment, IL-18, TNF-α, CD8+ increased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells decreased. After Huaiqihuang Granules treatment, IL-18, TNF-α, CD8+ decreased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells increased.ConclusionFunctions of cell immunity and humoral immunity in PNS patients before treatment were suppressed and disordered. Huaiqihuang granules can play a role in immunoregulation, with slight side reactions.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

https://www.degruyter.com/downloadpdf/journals/biol/14/1/article-p519.xml

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