New progress in understanding the cellular mechanisms of anti-arrhythmic drugs

Author:

An Zhe1,Yang Guang2,Liu Xuanxuan1,Zhang Zhongfan1,Liu Guohui1

Affiliation:

1. Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, P.R. China

2. Department of Molecular Biology, College of Basic Medical Science, Jilin University, Changchun 130033, Jilin, P.R. China

Abstract

AbstractAntiarrhythmic drugs are widely used, however, their efficacy is moderate and they can have serious side effects. Even if catheter ablation is effective for the treatment of atrial fibrillation and ventricular tachycardia, antiarrhythmic drugs are still important tools for the treatment of arrhythmia. Despite efforts, the development of antiarrhythmic drugs is still slow due to the limited understanding of the role of various ionic currents. This review summarizes the new targets and mechanisms of antiarrhythmic drugs.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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