A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women

Author:

Jia Xinzhuan1,Wei Lan2,Zhang Na1,Zheng Bolin1,Li Mengya1,Wang Hongxia3,Liu Erhuan4,Xu Jie3,Sun Guangyu3,Zhang Zhengmao5

Affiliation:

1. Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University , Shijiazhuang 050041, Hebei Province , China

2. Hebei Chest Hospital , Shijiazhuang 050041, Hebei Province , China

3. Department of Gynaecology, The Fourth Hospital of Hebei Medical University , Shijiazhuang 050041, Hebei Province , China

4. Shenzhou People’s Hospital , Shenzhou , 053800, Hebei Province , China

5. Department of Gynaecology, The Fourth Hospital of Hebei Medical University , No. 12, Jiankang Road , Shijiazhuang 050041, Hebei Province , China

Abstract

Abstract In areas with high incidence of tuberculosis (TB), there are more infertile women who underwent in vitro fertilization (IVF) and have latent TB infection (LTBI), and thus, their potential risks should be paid enough attention. The purpose of our study aimed to analyze the relationship between LTBI and clinical pregnancy outcomes of IVF and fresh embryo transfer (IVF–FET). This was a retrospective study of 628 infertile women who had undergone IVF–FET in the Fourth Affiliated Hospital of Hebei Medical University from January 2019 to December 2021. The women experienced no clinical symptoms, negative imaging, and T-SPOT.TB-positive diagnosis of LTBI. We divided the study population into the LTBI group and the non-LTBI group. The clinical pregnancy rate in the LTBI group was significantly lower than that in the non-LTBI group (40.54% vs 49.51%, P = 0.031), and there was no significant difference in live birth rate and miscarriage rate between the two groups. Logistic regression analysis showed that LTBI was an independent risk factor for decreased clinical pregnancy rate in infertile women undergoing IVF–FET. In conclusion, LTBI affects clinical pregnancy rate of IVF–FET in infertile women, and therefore, clinicians (especially in countries with a high TB burden) need to pay attention to LTBI before IVF and embryo transfer.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Reference20 articles.

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