Author:
Sfiridaki Aikaterini,Miyakis Spiros,Tsirakis George,Alegakis Athanassios,Passam Andreas M.,Kandidaki Ermioni,Margioris Andrew N.,Alexandrakis Michael G.
Abstract
AbstractMultiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma-produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examined the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption.Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78±91.27 vs. 59.25±33.09 ng/mL, p<0.004). Additionally, free urine pyridinolines (F-Pyd), free urine deoxy-pyridinolines (F-Dpd) and urine N-telopeptide fragment (NTx) were elevated, their level correlating with disease stage (p<0.001, p<0.03, p<0.001, respectively), as were bone marrow infiltration and serum interleukin-6 (IL-6) levels (p<0.0001, p<0.01, respectively). MMP-9 levels were lower in patients compared with controls (p<0.001), whereas IL-6 and bone resorption marker levels were higher in patients than in controls (p<0.001 in all cases). Significant correlation was found between infiltration, MMP-9, free urine pyd, free urine dpd and NTx for each stage of the disease (p<0.03, p<0.003, p<0.002, p<0.003 and p<0.001, respectively). Levels of MMP-9 and of IL-6 in multiple myeloma correlate well with bone turnover rate and may be useful in disease evaluation.
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
Reference27 articles.
1. The hepatocyte growth factor / Met pathway controls proliferation and apoptosis in multiple myeloma;Derksen;Leukemia,2003
2. Mast cells : the Jekyll and Hyde of tumor growth;Theoharides;Trends Immunol,2004
3. Matrix metalloproteinases in multiple myeloma;Kelly;Leuk Lymphoma,2000
4. Metalloproteinases in multiple myeloma : production of matrix metalloproteinase activation of proMMP and induction of MMP - by myeloma cells;Barille;Blood,1997
5. Margioris AN Evaluation of bone disease in multiple myeloma : a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients;Alexandrakis;Clin Chim Acta,2002
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献