The molecular biology of selenocysteine-Reference-Cited by-同舟云学术

The molecular biology of selenocysteine

Published:2013-08-01 Issue:4 Volume:4 Page:349-365
ISSN:1868-503X
Container-title:BioMolecular Concepts
language:
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Author:

Gonzalez-Flores Jonathan N.¹,Shetty Sumangala P.¹,Dubey Aditi¹,Copeland Paul R.¹

Affiliation:

1. 1Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA

Abstract

AbstractSelenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a set of factors that exist solely to incorporate this important amino acid. The mechanism by which this process occurs, put into the context of selenoprotein biology, is the focus of this review.

Publisher

Walter de Gruyter GmbH

Subject

Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.degruyter.com/downloadpdf/journals/bmc/4/4/article-p349.xml

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