New insights on solvent implications in flow behavior and interfacial interactions of hydroxypropylmethyl cellulose with cells/bacteria

Abstract

AbstractThe properties of polymers in solutions are affected by the solvent characteristics used in the processing stage. This work contributes to understanding the conformation changes under shear rheology of hydroxypropylmethyl cellulose (HPMC) in different solvents. Flow behavior in a large shear rate domain provides information on establishing the proper conditions in which the polymer solutions can be processed into uniform films. It was found that HPMC/solvent interactions influence the final architecture of macromolecules in the solid phase and implicitly the organization of polar/non-polar groups at the surface. This led to variable wettability and consequently to adhesion or cohesion of HPMC with biological agents. These new findings are important in tuning surface properties as demanded in bioengineering or regenerative medicine, where it is essential to establish adequate spreading conditions at the HPMC interface with cells or bacteria.