Amniotic fluid concentrations of soluble endoglin and endothelial cell-specific molecule-1 in pregnancies complicated with neural tube defects

Author:

Ovayolu Ali1ORCID,Ovayolu Gamze2,Yuce Tuncay3,Ozek Murat Aykut3,Dogan Ilkay4,Bostancieri Nuray5

Affiliation:

1. Cengiz Gokcek Public Hospital, Department of Obstetrics and Gynecology , Osmangazi Mahallesi, Cengiz Gokcek Kadin Hastaliklari ve Dogum Hastanesi , 27010 Gaziantep , Turkey , GSM: +90 (532) 640 40 60, Tel.: +90 342 360 08 88, Fax: +90 342 360 02 90

2. Umay IVF Center , Gaziantep , Turkey

3. Cengiz Gokcek Public Hospital, Department of Obstetrics and Gynecology , Gaziantep , Turkey

4. Department of Biostatistics, Faculty of Medicine , Gaziantep University , Gaziantep , Turkey

5. Department of Histology and Embryology , Gaziantep University School of Medicine , Gaziantep , Turkey

Abstract

Abstract Objective To determine the concentrations of soluble endoglin (sCD105) and endothelial cell-specific molecule-1 (ESM-1) in the amniotic fluid (AF) of pregnant women, and to investigate the relationship between these concentrations and neural tube defects (NTDs). Methods AF concentrations of sCD105 and ESM-1 were measured in the study group, which included 60 pregnant women complicated with NTDs, and 64 pregnant women with unaffected healthy fetuses (control group). The AF concentrations of sCD105 and ESM-1 in both groups were measured using enzyme-linked immunosorbent assay and compared. Results There were no significant differences in terms of the mean AF concentrations of sCD105 and ESM-1 between the groups (P=0.141, P=0.084, respectively). There was a significant difference between the AF sCD105 concentrations in those with gestational age <24 weeks (n=101) and ≥24 weeks (n=23) (X̅<24=76.35±126.62 vs. X 24=39.87±58.32, P=0.041). AF ESM-1 concentrations were found to be statistically significant in the gestational age <22 weeks (n=90) and ≥22 weeks (n=34) groups (X̅ <22=135.91±19.26 vs. X̅ 22=148.56±46.85, P=0.035). A positive and low-level relation at a statistically significant level was determined between the gestational age and AF ESM-1 concentration in the study group (r=0.257; P=0.048). Conclusion AF concentrations of sCD105 and ESM-1 were not associated with the development of NTDs. Unlike studies that reported that ESM-1 concentrations decreased in maternal plasma with increased gestational age, we determined an increase that was proportionate to gestational age in AF.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

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