Affiliation:
1. School of Laboratory Medicine, Chongqing Medical University , Chongqing 40016 , P.R. China
2. Department of Orthopedics , The First Affiliated Hospital of Chongqing Medical University , Chongqing 40016 , P.R. China
Abstract
Abstract
Osteosarcoma (OS) is the most prevalent malignant bone tumor with poor prognosis. Developing new drugs for the chemotherapy of OS has been a focal point and a major obstacle of OS treatment. Nitazoxanide (NTZ), a conventional anti-parasitic agent, has got increasingly noticed because of its favorable antitumor potential. Herein, we investigated the effect of NTZ on human OS cells in vitro and in vivo. The results obtained in vitro showed that NTZ inhibited the proliferation, migration and invasion, arrested cell cycle at G1 phase, while induced apoptosis of OS cells. Mechanistically, NTZ suppressed the activity of AKT/mTOR and Wnt/β-catenin signaling pathways of OS cells. Consistent with the results in vitro, orthotopic implantation model of 143B OS cells further confirmed that NTZ inhibited OS cells growth and lung metastasis in vivo. Notably, NTZ caused no apparent damage to normal cells/tissues. In conclusion, NTZ may inhibit tumor growth and metastasis of human OS cells through suppressing AKT/mTOR and Wnt/β-catenin signaling pathways.
Funder
the Natural Science Foundation Project of Chongqing Science and Technology CommissionThere is no funder DOI
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Cited by
8 articles.
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