Neprilysin 4: an essential peptidase with multifaceted physiological relevance

Author:

Buhr Annika1,Schiemann Ronja1,Meyer Heiko12ORCID

Affiliation:

1. Department of Biology/Chemistry, Zoology and Developmental Biology Section , Osnabruck University , Barbarastrasse 11, D-49076 Osnabruck , Germany

2. Center for Cellular Nanoanalytics (CellNanOs) , Barbarastrasse 11, D-49076 Osnabruck , Germany

Abstract

Abstract Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance of the peptidase. Particular attention is paid to the role of the neprilysin in regulating feeding behavior and the expression of insulin-like peptides in the central nervous system. In addition, we assess the function of the peptidase in controlling the activity of the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase in myocytes, as well as the underlying molecular mechanism in detail.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

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