New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals-Reference-Cited by-同舟云学术

New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals

Published:2022-09-26 Issue:11-12 Volume:403 Page:1005-1015
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Stuehr Dennis J.¹,Dai Yue¹,Biswas Pranjal¹^ORCID,Sweeny Elizabeth A.²,Ghosh Arnab¹

Affiliation:

1. Department of Inflammation and Immunity , Lerner Research Institute, Cleveland Clinic , 9500 Euclid Avenue , Cleveland , OH 44195 , USA

2. Department of Biochemistry , Medical College of Wisconsin , Milwaukee , WI 53226 , USA

Abstract

Abstract The intracellular trafficking of mitochondrial heme presents a fundamental challenge to animal cells. This article provides some background on heme allocation, discusses some of the concepts, and then reviews research done over the last decade, much in the author’s laboratory, that is uncovering unexpected and important roles for glyceraldehyde 3-phosphate dehydrogenase (GAPDH), heat shock protein 90 (hsp90), and nitric oxide (NO) in enabling and regulating the allocation of mitochondrial heme to hemeproteins that mature and function outside of the mitochondria. A model for how hemeprotein functions can be regulated in cells through the coordinate participation of GAPDH, hsp90, and NO in allocating cellular heme is presented.

Funder

National Institute of Health Grants – Programme Grants for Applied Research

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2022-0197/pdf

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