Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors

Author:

Sokolova Anastasiia12ORCID,Galic Milos13ORCID

Affiliation:

1. Institute of Medical Physics and Biophysics , University of Münster , Robert-Koch-Straße 31, 48149 Münster , Germany

2. CiM-IMRPS Graduate Program , Schlossplatz 5, 48149 Münster , Germany

3. ‘Cells in Motion’ Interfaculty Centre , University of Münster , Röntgenstraße 16, 48149 Münster , Germany

Abstract

Abstract Mechanical forces exerted to the plasma membrane induce cell shape changes. These transient shape changes trigger, among others, enrichment of curvature-sensitive molecules at deforming membrane sites. Strikingly, some curvature-sensing molecules not only detect membrane deformation but can also alter the amplitude of forces that caused to shape changes in the first place. This dual ability of sensing and inducing membrane deformation leads to the formation of curvature-dependent self-organizing signaling circuits. How these cell-autonomous circuits are affected by auxiliary parameters from inside and outside of the cell has remained largely elusive. Here, we explore how such factors modulate self-organization at the micro-scale and its emerging properties at the macroscale.

Funder

Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Münster

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

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