Influence of irisin on diet-induced metabolic syndrome in experimental rat model
Author:
Medhat Dalia1ORCID, El-Bana Mona A.1, El-Daly Sherien M.1, Ashour Magdi N.1, Elias Tahany R.1, Mohamed Rehab A.1, Yassen Noha N.2, Abdel-Monem Mahmoud A.1, Hussein Jihan1
Affiliation:
1. Medical Biochemistry Department , National Research Centre , Doki, Giza , Egypt 2. Pathology Department, Medical Division , National Research Centre , Doki, Giza , Egypt
Abstract
Abstract
Objective
To evaluate the influence of irisin on the experimental paradigm of non-alcoholic fatty liver (NAFL) as a part of MetS cluster.
Methods
Forty male albino rats were divided into four groups; normal control, standard diet + irisin, high carbohydrate and fat diet (HCHF), and HCHF + irisin. After the experimental period, levels of fasting blood sugar (FBS), insulin, lipid profile, kidney functions, salusin-alpha (Sal-α), adropin, and retinol-binding protein-4 (RBP-4) were evaluated. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α) expression in skeletal muscle was evaluated by quantitative real-time PCR. Aorta, liver, pancreas, and skeletal muscle tissue samples were prepared for histopathological examination.
Results
Rats administrated HCHF showed elevated levels of FBS, lipid profile, kidney functions, RBP-4, and downregulation of PGC-1α expression along with a decline in levels of insulin, Sal-α, and adropin while administration of irisin significantly attenuated these levels.
Conclusions
Irisin as based therapy could emerge as a new line of treatment against MetS and its related diseases.
Funder
National Research Centre
Publisher
Walter de Gruyter GmbH
Subject
Complementary and alternative medicine
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