Affiliation:
1. Department of Moalajat , Luqman Unani Medical College Hospital & Research Center , Bijapur , Karnataka , India
2. National Research Institute of Unani Medicine for Skin Disorders , Hyderabad , India
Abstract
Abstract
Objectives
Greco-Arab medicine is an ancient system of medicine with greater treasure on therapeutics of vitiligo. The trial Unani formulations have not been scientifically explored for their safety and efficacy, but have been repeatedly prescribed by the great Unani physicians in the management of Baraṣ (vitiligo). Hence, these interventions were selected for the trial.
Methods
In this randomized, controlled, open-label clinical trial, 82 participants with non-segmental vitiligo aged 18–40 years were block randomized to either receive Unani interventions or control for 16 weeks. Out of 82 participants, 42 were randomized to the Unani group and 40 were randomized to the control group. The primary outcome measure was change in vitiligo area scoring index (VASI), which was assessed on weeks 4, 8, 12 and 16. The secondary outcome measures included the patient’s global assessment on VAS and investigator’s global assessment based on photographic evaluation at baseline and after the treatment. Safety parameters included hemogram, LFTs, RFTs, CXR, ECG, urine, and stool examinations, which were evaluated at baseline and after the treatment.
Results
The per-protocol analysis was done on 30 participants in each group and the response in Unani group was not inferior to those receiving control group. The mean ± SD of vitiligo area scoring index (VASI) decreased from 4.09 ± 2.87 and 5.50 ± 5.73 at baseline to 3.13 ± 2.20 and 4.29 ± 4.95 at the end of the trial in both the Unani and control groups respectively.
Conclusions
The study inferred that both the interventions are equally effective and well-tolerated in patients with non-segmental vitiligo.
Subject
Complementary and alternative medicine
Reference42 articles.
1. Christopher, G, Barker, J, Bleiker, T, Robert, C, Creamer, D. Acquired Pigmentary Disorders. Rook’s Textb. Dermatology, 9th ed., vol. 3. Wiley-Blackwell; 2016:88.34–6 pp.
2. Ezzedine, K, Sheth, V, Rodrigues, M, Eleftheriadou, V, Harris, JE, Hamzavi, IH, et al.. Vitiligo is not a cosmetic disease. J Am Acad Dermatol 2015;73:883–5. https://doi.org/10.1016/j.jaad.2015.07.039.
3. Porter, J, Beuf, A, Nordlund, JJ, Lerner, AB. Personal responses of patients to vitiligo: the importance of the patient-physician interaction. Arch Dermatol 1978;114:1384–5. https://doi.org/10.1001/archderm.1978.01640210075025.
4. Krüger, C, Schallreuter, KU. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Int J Dermatol 2012;51:1206–12. https://doi.org/10.1111/j.1365-4632.2011.05377.x.
5. Yaghoobi, R, Omidian, M, Bagherani, N. Vitiligo: a review of the published work. J Dermatol 2011;38:419–31. https://doi.org/10.1111/j.1346-8138.2010.01139.x.
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