Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients-Reference-Cited by-同舟云学术

Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients

Published:2024-01-10 Issue:1 Volume:21 Page:131-138
ISSN:1553-3840
Container-title:Journal of Complementary and Integrative Medicine
language:en
Short-container-title:

Author:

Sadek Ahmed¹,Abd El Hady Ahmed M.²,Olfat Hammam²,Abd El Hady Afaf A.³,Wafy Wafaa⁴,Zaki Moushira⁵^ORCID,Youness Eman R.⁶

Affiliation:

1. Departments of Hepatology & Gastroenterology , Theodor Bilharz Research Institute , Giza , Egypt

2. Departments of Pathology , Theodor Bilharz Research Institute , Giza , Egypt

3. Departments of Clinical Chemistry , Theodor Bilharz Research Institute , Giza , Egypt

4. Departments of Public Health , Theodor Bilharz Research Institute , Giza , Egypt

5. Department of Biological Anthropology , Medical Researches and Clinical Studies Institute, National Research Centre , Cairo , Egypt

6. Department of Medical Biochemistry , Medical Researches and Clinical Studies Institute, National Research Centre , Cairo , Egypt

Abstract

Abstract Objectives We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect of giving multiple anti-oxidants with the ozone/oxygen gas mixture, to see if this addition would have any additive or synergistic effect. Methods Two hundred and twenty three patients with chronic hepatitis C. Liver biopsies were carried out at after 12 weeks of administering an ozone/oxygen gas mixture. Results The mean stage of fibrosis decreased from 1.98 to 1.41 and the mean grade of inflammation decreased from 10.08 to 7.94, both with a p value less than 0.001. After 12 weeks of treatment, mean PCR values increased. No single significant complication was recorded in a total of >9,000 settings of ozone therapy. Conclusions Ozone oxygen gas mixture is safe and effective in treatment of hepatic fibrosis due to chronic viral hepatitis C.

Funder

no funding

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/jcim-2023-0239/pdf

Reference31 articles.

1. Jamison, DT, Summers, LH, Alleyne, G, Arrow, KJ, Berkley, S, Binagwaho, A, et al.. Global health 2035: a world converging within a generation. Lancet 2013;382:1898–955.

2. Organization WH. Global health estimates. Geneva: World Heal. Organ.; 2012.

3. Dolnikov, S, Adam, R, Cherqui, D, Allard, MA. Liver transplantation in elderly patients: what do we know at the beginning of 2020? Surg Today 2020;50:533–9.

4. Kim, AY, Chung, RT. Coinfection with HIV-1 and HCV – a one-two punch. Gastroenterology 2009;137:795–814.

5. Jani, P, Patel, G, Yadav, P, Sant, L, Jain, H. Ozone therapy: the alternative medicine of future. Indian J Phys Med Rehabil 2012;2:196–203.