Affiliation:
1. Department of Medical Physiology , Medical Research and Clinical Studies Institute, National Research Centre , Dokki , Cairo , Egypt
2. Department of Pathology, Faculty of Veterinary Medicine , Cairo University , Giza , Egypt
Abstract
Abstract
Objectives
Favism is a metabolic disease and this study aimed to compare between olive oil and almond oil to ameliorate blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology in favism rats.
Methods
Animals were 36 male albino rats. They classified to 2 equal (normal and favism) groups. Normal group classified to 3 equal subgroups; Control, Olive oil, and Almond oil subgroups: normal rats orally administrated with 1 mL/100 g of saline, olive oil, and almond oil, respectively. Favism group was subdivided into 3 equal subgroup; favism, favism + olive oil, and favism + almond oil subgroups: favism rats orally administrated with no treatment, 1 mL/100 g olive oil, and 1 mL/100 g almond oil, respectively. All treatments were administrated orally by oral gavage once a day for 1 month.
Results
The hemoglobin, hematocrite, the blood cells, glucose and glucose-6-phosphate dehydrogenase, aspartate and alanine aminotransferase, total proteins, albumin, and globulin in serum were decreased in favism. The glutathione, superoxide dismutase, and glutathione peroxidase in blood and liver were decreased in favism while alkaline phosphatase and total bilirubin in serum were increased in favism. The blood and liver malondialdehyde was increased in favism. Furthermore, oral administration with both oils in favism rats restored all these parameters to be approached the control levels. Also, both oils preserved blood and liver DNA and liver histology.
Conclusions
Almond oil restored blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism.
Subject
Complementary and alternative medicine
Reference47 articles.
1. McMillan, DC, Jollow, DJ. Favism: divicine hemotoxicity in the rat. Toxicol Sci 1999;51:310–6. https://doi.org/10.1093/toxsci/51.2.310.
2. Bicakci, Z. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (vetch). Saudi Med J 2009;30:292–4.
3. Arese, P, Mannuzzu, L, Turrini, F. Pathophysiology of favism. Folia Haematol 1989;116:745–52.
4. Albano, E, Tomasi, A, Mannuzzu, L, Arese, P. Detection of free radical intermediate from divicine of Vicia faba. Biochem Pharmacol 1984;33:1701–4. https://doi.org/10.1016/0006-2952(84)90299-5.
5. Marquardt, RR. Vicine, convicine and their role aglycnes-divine and isouramil. In: Cheeke, P, editor. Toxicants of plant origin, 2nd ed. Boca Raton, F l., New York, USA: CRC Press; 1989:614–23 pp.