Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease

Abstract

Abstract One of the current strategies in the treatment of Alzheimer’s disease is using drugs with acetylcholinesterase (AChE) inhibitory property. The existence of various compounds in plants as a potential source for finding new compounds to treat Alzheimer’s disease is a scientific fact. Many secondary metabolites and plant extracts have been reported with the ability to inhibit the AChE activity and improve memory and learning. These compounds can increase the concentration of acetylcholine in the brain and improve cholinergic function in individuals with Alzheimer’s disease and reduce the symptoms of this neurological disorder. Plants of Ferula genus are a good source of biologically active compounds such as sesquiterpene derivatives, coumarin derivatives and sulfur-containing compounds. Numerous studies on various extracts or purified compounds of Ferula genus have shown that members of this genus have the inhibitory properties on acetylcholinesterase and can also be effective in improving Alzheimer’s and amnesia. This review article summarizes studies on plants of Ferula extracts and their derived compounds to find AChE inhibitors.