The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial

Author:

Manjiri Mohammad Azad1,Asadpour Amir Abbas2,Yousefi Mahdi1,Jamali Jamshid3ORCID,Davachi Behrooz4,Ahmadpour Mohammad Reza1,Salari Roshanak5

Affiliation:

1. Department of Persian Medicine, School of Persian and Complementary Medicine , Mashhad University of Medical Sciences , Mashhad , Iran

2. Department of Urology, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran

3. Department of Biostatistics, School of Health , Mashhad University of Medical Sciences , Mashhad , Iran

4. Department of Radiology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran

5. Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine , Mashhad University of Medical Sciences , Mashhad , Iran

Abstract

Abstract Objectives Given high and growing prevalence rate of urolithiasis in most societies as well as the problems caused by this issue, it is necessary to apply more cost-effective and safer therapeutic methods, which are accessible for all the individuals worldwide. Therefore, this study aimed to investigate efficacy of herbal medicines named Cynodon dactylon and Dolichos biflorus on solving and excretion of renal and urinary tract stones in patients with urolithiasis. Methods This study included 96 patients with urolithiasis who were randomly allocated into three groups. The first group received the extract of D. biflorus seeds (1,600 mg), the second group received extract of C. dactylon rhizome (1,600 mg) and the third group received placebo for 21 days. In this study, we used an hydroalcoholic extract of D. biflorus and C. dactylon prepared by Soxhlet method. For each patient, the size of the stones, the amount of calcium in the urine, the number of stones excreted and their chemical substance type were measured. Results In this study, changes were observed at the significance level in the interventions groups of 1 and 2, and the placebo group in the left kidney, so that changes in size of the stone in left kidney as intergroup were significantly different in these three groups (p=0.02). The mean of changes in stone size in left kidney in the group C. dactylon was 3.78 ± 7.1 and in the group D. biflorus, it was 0.27 ± 0.6. Conclusions A significant difference in the results of this study show that C. dactylon rhizome and D. biflorus seed extracts are able to decrease the size of the stone and can be effective on kidney stones excretion.

Funder

Mashhad University of Medical Sciences

Publisher

Walter de Gruyter GmbH

Subject

Complementary and alternative medicine

Reference48 articles.

1. Wang, W, Fan, J, Huang, G, Li, J, Zhu, X, Tian, Y, et al.. Prevalence of kidney stones in mainland China: a systematic review. Sci Rep 2017;7:1–9. https://doi.org/10.1038/srep41630.

2. McAninch, JW, Lue, TF. Smith & Tanagho’s general urology. New York: McGraw-Hill Medical; 2013.

3. Pearle, MS, Antonelli, JA, Iotan, Y. Campbell-walsh urology, 11th ed. Philadelphia: Elsevier; 2016, 2:1170–200 pp.

4. Khan, SR. Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome? Urol Res 2012;40:95–112. https://doi.org/10.1007/s00240-011-0448-9.

5. Golshan, A, Hayatdavoudi, P, Mousa, A, Rad, AK, Roshan, NM, Abbasnezhad, A, et al.. Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male Wistar rats. Avicenna J Phytomedicine 2017;7:180.

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3