Antipyretic activity of the hydro-alcoholic extract of <i>Artemisia absinthium</i> L. as a standalone and as an adjuvant with barley water against yeast-induced pyrexia in albino Wistar rats-Reference-Cited by-同舟云学术

Antipyretic activity of the hydro-alcoholic extract of Artemisia absinthium L. as a standalone and as an adjuvant with barley water against yeast-induced pyrexia in albino Wistar rats

Published:2023-12-19 Issue:0 Volume:0 Page:
ISSN:2194-6329
Container-title:Journal of Complementary and Integrative Medicine
language:en
Short-container-title:

Author:

Bhat Mohd Musaib¹,Ansari Athar Pervez²^ORCID,Ahmad Ansar³,Qayoom Ifra⁴,Reshi Bazilah Majeed³

Affiliation:

1. ICMR INDIAB, Department of Clinical Research , Sher-i-Kashmir Institute of Medical Sciences , Srinagar , India

2. Regional Research Institute of Unani Medicine, Chennai (NABH & NABL Accredited) , Central Council for Research in Unani Medicine, Ministry of Ayush, Govt. of India , Chennai , India

3. Research Institute of Unani Medicine, Srinagar (NABH Accredited) , Central Council for Research in Unani Medicine, Ministry of Ayush, Govt. of India , Srinagar , India

4. Kashmir Tibbia College, Hospital & Research Center , University of Kashmir , Srinagar , India

Abstract

Abstract Objectives In Unani medicine, a comprehensive treatment plan has been delineated to deal with febrile illnesses using herbal drugs along with modified dietetics, which stands as a promising area of research. The present study was aimed at evaluating the antipyretic activity of the HAE of Artemisia absinthium L. whole plant as a standalone and as an adjuvant with barley water in an animal model of pyrexia to validate the age-old Unani principle of the treatment. Methods The pyrexia was induced in all the groups except the plain control using Brewer’s yeast. Group II did not receive any treatment, while group III received crocin, group IV received HAE of A. absinthium, group V administered Ma al-Sha’ir, and group VI was treated with the HAE of A. absinthium along with Ma al-Sha’ir by oral route. The rectal temperature of each rat was recorded at ‘0’ h, 30 min, 60 min, and 180 min. Results The mean rectal temperature of group III went down from 101.82±0.20 °F to 100.4±0.57 °F over the period of (0–180) minutes, whereas the mean temperature in group IV went down from 102.45±0.60 °F to 100.14±0.57 °F. The mean rectal temperature of group V decreased from 100.62±0.11 °F to 99.55±0.51 °F, while the mean rectal temperature of group VI went down from 101.95±0.1 °F to 97.7±0.11 °F. Conclusions It is concluded that the HAE of A. absinthium L. as a standalone and along with Ma al Sha’ir showed excellent antipyretic activity as compared to the standard drug in an animal model.

Publisher

Walter de Gruyter GmbH

Subject

Complementary and alternative medicine

Link

https://www.degruyter.com/document/doi/10.1515/jcim-2023-0307/pdf

Reference31 articles.

1. Sullivan, JE, Farrar, HC. Fever and antipyretic use in children. Pediatrics 2011;127:580–7. https://doi.org/10.1542/peds.2010-3852.

2. Kiekkas, P, Aretha, D, Bakalis, N, Karpouhtsi, I, Marneras, C, Baltopoulos, GI. Fever effects and treatment in critical care: literature review. Aust Crit Care 2013;26:130–5. https://doi.org/10.1016/j.aucc.2012.10.004.

3. Gensini, GF, Conti, AA. The evolution of the concept of fever in the history of medicine: from pathological picture per se to clinical epiphenomenon. J Infect 2004;49:85–7. https://doi.org/10.1016/j.jinf.2003.11.003.

4. Kushidayati, L. Ibn al-Jazzar on fevers: a critical edition of Zad al-Musafir wa-Qut al-Hadir by Gerrit Boss. Qudus Int J Islamic Stud 2014;2:183–97.

5. Joel, GH, Lee, EL, Alfred, GG. Analgesic, antipyretic and anti-inflammatory agents. In: Goodman and Gilman’s: the pharmacological basis of therapeutics, 13th ed. USA: McGraw-Hill, Medical Publishing Division; 2018:687–93 pp.