Patient-derived iPSCs, a reliable in vitro model for the investigation of Alzheimer’s disease
Author:
Amponsah Asiamah Ernest12, Guo Ruiyun12, Kong Desheng12, Feng Baofeng12, He Jingjing12, Zhang Wei12, Liu Xin12, Du Xiaofeng12, Ma Zhenhuan12, Liu Boxin12, Ma Jun123, Cui Huixian123
Affiliation:
1. Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University , Shijiazhuang , Hebei Province 050017 , China 2. Hebei Research Center for Stem Cell Medical Translational Engineering , Shijiazhuang , Hebei Province 050017 , China 3. Human Anatomy Department , Hebei Medical University , Shijiazhuang , Hebei Province 050017 , China
Abstract
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease and a common cause of dementia among elderly individuals. The disease is characterized by progressive cognitive decline, accumulation of senile amyloid plaques and neurofibrillary tangles, oxidative stress, and inflammation. Human-derived cell models of AD are scarce, and over the years, non-human-derived models have been developed to recapitulate clinical AD, investigate the disease’s pathogenesis and develop therapies for the disease. Several pharmacological compounds have been developed for AD based on findings from non-human-derived cell models; however, these pharmacological compounds have failed at different phases of clinical trials. This necessitates the application of human-derived cell models, such as induced pluripotent stem cells (iPSCs) in their optimized form in AD mechanistic studies and preclinical drug testing. This review provides an overview of AD and iPSCs. The AD-relevant phenotypes of iPSC-derived AD brain cells and the usefulness of iPSCs in AD are highlighted. Finally, the various recommendations that have been made to enhance iPSC/AD modelling are discussed.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
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