Brain metabolic DNA: recent evidence for a mitochondrial connection-Reference-Cited by-同舟云学术

Brain metabolic DNA: recent evidence for a mitochondrial connection

Published:2021-01-27 Issue:1 Volume:32 Page:93-100
ISSN:2191-0200
Container-title:Reviews in the Neurosciences
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Author:

Giuditta Antonio¹,Grassi Zucconi Gigliola²,Sadile Adolfo³

Affiliation:

1. Accademia di Scienze Fisiche e Matematiche, Via Mezzocannone 8, Naples, I-80134, Italy

2. Department of Neuroscience, University of Verona, Strada Le Grazie 8, Verona, I-37129, Italy

3. Department of Experimental Medicine, L. Vanvitelli Medical School, University Campania, Via S. Andrea delle dame 7, Naples, I-80138, Italy

Abstract

AbstractThis review highlights recent data concerning the synthesis of brain metabolic DNA (BMD) by cytoplasmic reverse transcription and the prompt acquisition of the double-stranded configuration that allows its partial transfer to nuclei. BMD prevails in the mitochondrial fraction and is present in presynaptic regions and astroglial processes where it undergoes a turnover lasting a few weeks. Additional data demonstrate that BMD sequences are modified by learning, thus indicating that the modified synaptic activity allowing proper brain responses is encoded in learning BMD. In addition, several converging observations regarding the origin of BMD strongly suggest that BMD is reverse transcribed by mitochondrial telomerase.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2020-0050/pdf

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