Depression following traumatic brain injury: a comprehensive overview-Reference-Cited by-同舟云学术

Depression following traumatic brain injury: a comprehensive overview

Published:2020-12-23 Issue:3 Volume:32 Page:289-303
ISSN:2191-0200
Container-title:Reviews in the Neurosciences
language:en
Short-container-title:

Author:

Fakhoury Marc¹²^ORCID,Shakkour Zaynab³^ORCID,Kobeissy Firas³,Lawand Nada¹⁴

Affiliation:

1. Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine , American University of Beirut , Beirut , Lebanon

2. Department of Natural Sciences, School of Arts and Sciences , Lebanese American University , Beirut , Lebanon

3. Department of Biochemistry and Molecular Genetics, Faculty of Medicine , American University of Beirut , Beirut , Lebanon

4. Department of Neurology, Faculty of Medicine , American University of Beirut , Beirut , Lebanon

Abstract

AbstractTraumatic brain injury (TBI) represents a major health concern affecting the neuropsychological health; TBI is accompanied by drastic long-term adverse complications that can influence many aspects of the life of affected individuals. A substantial number of studies have shown that mood disorders, particularly depression, are the most frequent complications encountered in individuals with TBI. Post-traumatic depression (P-TD) is present in approximately 30% of individuals with TBI, with the majority of individuals experiencing symptoms of depression during the first year following head injury. To date, the mechanisms of P-TD are far from being fully understood, and effective treatments that completely halt this condition are still lacking. The aim of this review is to outline the current state of knowledge on the prevalence and risk factors of P-TD, to discuss the accompanying brain changes at the anatomical, molecular and functional levels, and to discuss current approaches used for the treatment of P-TD.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2020-0037/pdf

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