Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins-Reference-Cited by-同舟云学术

Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins

Published:2021-02-15 Issue:6 Volume:32 Page:615-629
ISSN:2191-0200
Container-title:Reviews in the Neurosciences
language:en
Short-container-title:

Author:

Liang Juan¹²,Wang Huiqing¹²,Zeng Yan¹²,Qu Yi¹²,Liu Qian¹²,Zhao Fengyan¹²,Duan Jianan³,Jiang Yin¹²,Li Shiping¹²,Ying Junjie¹²,Li Jinhui¹²,Mu Dezhi¹²

Affiliation:

1. Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China

2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education) , West China Second University Hospital, Sichuan University , Chengdu 610041 , China

3. West China Hospital, Sichuan University , Chengdu 610041 , China

Abstract

Abstract Exercise has been shown to have beneficial effects on brain functions in humans and animals. Exercise can improve memory and learning in age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity and hippocampal neurogenesis, regulates the expression levels of neurotrophic factors, and improves cognitive function. Therefore, exercise is very important for brain rehabilitation and remodeling. The purpose of this review is to explore the mechanisms by which exercise exerts positive effects on brain function. This knowledge implies that physical exercise can be used as a non-drug therapy for neurological diseases.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2020-0099/pdf

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