Intranasal application of stem cells and their derivatives as a new hope in the treatment of cerebral hypoxia/ischemia: a review
Author:
Salehi Mohammad Saied1, Jurek Benjamin2ORCID, Karimi-Haghighi Saeideh1, Nezhad Nahid Jashire1, Mousavi Seyedeh Maryam1, Hooshmandi Etrat1, Safari Anahid3, Dianatpour Mehdi3, Haerteis Silke2, Miyan Jaleel A.4, Pandamooz Sareh3, Borhani-Haghighi Afshin1
Affiliation:
1. Clinical Neurology Research Center , Shiraz University of Medical Sciences , Shiraz 71936-35899 , Iran 2. Institute of Molecular and Cellular Anatomy , University of Regensburg , Regensburg 93053 , Germany 3. Stem Cells Technology Research Center , Shiraz University of Medical Sciences , Shiraz 71936-35899 , Iran 4. Faculty of Biology, Medicine & Health, Division of Neuroscience & Experimental Psychology , The University of Manchester , Manchester M13 9PL , UK
Abstract
Abstract
Intranasal delivery of stem cells and conditioned medium to target the brain has attracted major interest in the field of regenerative medicine. In pre-clinical investigations during the last ten years, several research groups focused on this strategy to treat cerebral hypoxia/ischemia in neonates as well as adults. In this review, we discuss the curative potential of stem cells, stem cell derivatives, and their delivery route via intranasal application to the hypoxic/ischemic brain. After intranasal application, stem cells migrate from the nasal cavity to the injured area and exert therapeutic effects by reducing brain tissue loss, enhancing endogenous neurogenesis, and modulating cerebral inflammation that leads to functional improvements. However, application of this administration route for delivering stem cells and/or therapeutic substances to the damaged sites requires further optimization to translate the findings of animal experiments to clinical trials.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
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