Role of ABC transporters in the pathology of Alzheimer’s disease-Reference-Cited by-同舟云学术

Role of ABC transporters in the pathology of Alzheimer’s disease

Published:2017-02-01 Issue:2 Volume:28 Page:155-159
ISSN:2191-0200
Container-title:Reviews in the Neurosciences
language:
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Author:

Zhao Yan¹,Hou Deren¹,Feng Xialu¹,Lin Fangbo¹,Luo Jing¹

Affiliation:

1. 1Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha HN 410013, China

Abstract

AbstractThe ATP-binding cassette (ABC) transporter superfamily is a large family of proteins that transport specific molecules across membranes. These proteins are associated with both cholesterol metabolism and Alzheimer’s disease (AD). Cholesterol homeostasis has a key role in AD, and ABC transporters are important mediators of lipid transportation. Emerging evidence suggests that decreased expression and hypofunction of ABC transporters are crucial to the occurrence and development of AD. In the present article, we review the current knowledge regarding ABC transporters and speculate on their role in the pathogenesis of AD.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2016-0060/pdf

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