Affiliation:
1. Université de Rouen, Département Psychologie, Laboratoire ICONES EA 4699, F-76821 Mont-Saint-Aignan Cedex, France
2. Université de Lorraine, Laboratoire ‘Stress, Immunité, Pathogènes’ EA 7300 and Service de Microscopie Electronique, Faculté de Médecine, 9 avenue de la Forêt de Haye, CHRU de Nancy, F-54500 Vandoeuvre-les-Nancy, France
Abstract
AbstractWhen injected via the intracerebroventricular route, corticosterone-releasing hormone (CRH) reduced exploration in the elevated plus-maze, the center region of the open-field, and the large chamber in the defensive withdrawal test. The anxiogenic action of CRH in the elevated plus-maze also occurred when infused in the basolateral amygdala, ventral hippocampus, lateral septum, bed nucleus of the stria terminalis, nucleus accumbens, periaqueductal grey, and medial frontal cortex. The anxiogenic action of CRH in the defensive withdrawal test was reproduced when injected in the locus coeruleus, while the amygdala, hippocampus, lateral septum, nucleus accumbens, and lateral globus pallidus contribute to center zone exploration in the open-field. In addition to elevated plus-maze and open-field tests, the amygdala appears as a target region for CRH-mediated anxiety in the elevated T-maze. Thus, the amygdala is the principal brain region identified with these three tests, and further research must identify the neural circuits underlying this form of anxiety.
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