Role of zinc and copper ions in the pathogenetic mechanisms of traumatic brain injury and Alzheimer’s disease

Author:

Isaev Nickolay K.12,Stelmashook Elena V.2,Genrikhs Elisaveta E.2

Affiliation:

1. M.V. Lomonosov Moscow State University, N.A. Belozersky Institute of Physico-Chemical Biology, Biological Faculty, Moscow 119991, Russia

2. Research Center of Neurology, Moscow 125367, Russia

Abstract

AbstractThe disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous system is involved in the pathogenesis of many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Wilson’s, Creutzfeldt-Jakob, Parkinson’s, and Alzheimer’s diseases (AD), and traumatic brain injury (TBI). The last two pathological conditions of the brain are the most common; moreover, it is possible that TBI is a risk factor for the development of AD. Disruptions of Zn2+and Cu2+homeostasis play an important role in the mechanisms of pathogenesis of both TBI and AD. This review attempts to summarize and systematize the currently available research data on this issue. The neurocytotoxicity of Cu2+and Zn2+, the synergism of the toxic effect of calcium and Zn2+ions on the mitochondria of neurons, and the interaction of Zn2+and Cu2+with β-amyloid (Abeta) and tau protein are considered.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Reference240 articles.

1. Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure;J. Neurosci. Res.,2010

2. Zinc in Alzheimer’s disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies;J. Alzheimers Dis.,2015

3. Chemical blocking of zinc ions in CNS increases neuronal damage following traumatic brain injury (TBI) in mice;PLoS One,2010

4. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release;J. Neurochem.,2000

5. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release;J. Neurochem.,2000

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