Pathological and cognitive changes in patients with type 2 diabetes mellitus and comorbid MCI and protective hypoglycemic therapies: a narrative review
Author:
Zhang Xiao1, Huang-Fu Zhao2, Lang Xing-Ying3, Chun Pu4, Chi Yan-Yan4, Yuan Xiao-Ying4, Wang Xu-Gang5
Affiliation:
1. The First Affiliated Hospital of Dalian Medical University , Dalian 116000 , P.R. China 2. The Second Affiliated Hospital of Dalian Medical University , Dalian 116027 , P.R. China 3. Dalian Center for Disease Control and Prevention , Dalian 116021 , P.R. China 4. Department of Anatomy, College of Basic Medicine , Dalian Medical University , Dalian 16044 , P.R. China 5. Department of Neurology , The Second Affiliated Hospital of Dalian Medical University , Dalian 116027 , P.R. China
Abstract
Abstract
Type 2 diabetes mellitus (T2DM) is becoming a significant health issue worldwide. Many studies support the hypothesis that patients with T2DM have a higher-than-expected incidence of mild cognitive impairment (MCI) than individuals without diabetes. Based on the results from recent studies, MCI might be associated with the effects of T2DM on glucose metabolism and brain atrophy. As a narrative review, we will illuminate pathological and cognitive changes in patients with T2DM and comorbid MCI and protective hypoglycemic therapies. The early abnormal signs of cognition must be elucidated, and extensive investigations are needed to develop improved therapies for use in the clinic.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
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