Research advancements on nerve guide conduits for nerve injury repair
Author:
Wang Shoushuai1, Wen Xinggui1, Fan Zheyuan1, Ding Xiangdong1, Wang Qianqian1, Liu Zhongling1, Yu Wei1
Affiliation:
1. China-Japan Union Hospital of Jilin University , 126 Xiantai Street , Changchun City 130033 , Jilin Province , China
Abstract
Abstract
Peripheral nerve injury (PNI) is one of the most serious causes of disability and loss of work capacity of younger individuals. Although PNS has a certain degree of regeneration, there are still challenges like disordered growth, neuroma formation, and incomplete regeneration. Regarding the management of PNI, conventional methods such as surgery, pharmacotherapy, and rehabilitative therapy. Treatment strategies vary depending on the severity of the injury. While for the long nerve defect, autologous nerve grafting is commonly recognized as the preferred surgical approach. Nevertheless, due to lack of donor sources, neurological deficits and the low regeneration efficiency of grafted nerves, nerve guide conduits (NGCs) are recognized as a future promising technology in recent years. This review provides a comprehensive overview of current treatments for PNI, and discusses NGCs from different perspectives, such as material, design, fabrication process, and composite function.
Funder
Norman Bethune Program of Jilin University Jilin Province Health Talent Special Project
Publisher
Walter de Gruyter GmbH
Reference116 articles.
1. Alike, Y., Yushan, M., Keremu, A., Abulaiti, A., Liu, Z.-H., Fu, W., Yan, L.-W., Yusufu, A., and Zhu, Q.-T. (2019). Application of custom anatomy-based nerve conduits on rabbit sciatic nerve defects: in vitro and in vivo evaluations. Neural Regen. Res. 14: 2173–2182, https://doi.org/10.4103/1673-5374.262601. 2. Al’joboori, Y., Hannah, R., Lenham, F., Borgas, P., Kremers, C.J., Bunday, K.L., Rothwell, J., and Duffell, L.D. (2021). The immediate and short-term effects of transcutaneous spinal cord stimulation and peripheral nerve stimulation on corticospinal excitability. Front. Neurosci. 15: 749042, https://doi.org/10.3389/fnins.2021.749042. 3. Al-Majed, A.A., Neumann, C.M., Brushart, T.M., and Gordon, T. (2000). Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J. Neurosci. 20: 2602–2608, https://doi.org/10.1523/jneurosci.20-07-02602.2000. 4. Beigom Hejazian, L., Esmaeilzade, B., Ghoroghi, F.M., Moradi, F., Hejazian, M.B., Aslani, A., Bakhtiari, M., Soleimani, M., and Nobakht, M. (2012). The role of biodegradable engineered nanofiber scaffolds seeded with hair follicle stem cells for tissue engineering. Iran Biomed. J. 16: 193–201. 5. Bryan, D.J., Tang, J.B., Doherty, S.A., Hile, D.D., Trantolo, D.J., Wise, D.L., and Summerhayes, I.C. (2004). Enhanced peripheral nerve regeneration through a poled bioresorbable poly (lactic-co-glycolic acid) guidance channel. J. Neural Eng. 1: 91, https://doi.org/10.1088/1741-2560/1/2/004.
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