The role of pain modulation pathway and related brain regions in pain
Author:
Yao Dandan12, Chen Yeru2, Chen Gang12
Affiliation:
1. Department of Anesthesiology , School of Medicine, Shaoxing University , Shaoxing , Zhejiang , China 2. Department of Anesthesiology , Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , 310058, China
Abstract
Abstract
Pain is a multifaceted process that encompasses unpleasant sensory and emotional experiences. The essence of the pain process is aversion, or perceived negative emotion. Central sensitization plays a significant role in initiating and perpetuating of chronic pain. Melzack proposed the concept of the “pain matrix”, in which brain regions associated with pain form an interconnected network, rather than being controlled by a singular brain region. This review aims to investigate distinct brain regions involved in pain and their interconnections. In addition, it also sheds light on the reciprocal connectivity between the ascending and descending pathways that participate in pain modulation. We review the involvement of various brain areas during pain and focus on understanding the connections among them, which can contribute to a better understanding of pain mechanisms and provide opportunities for further research on therapies for improved pain management.
Funder
Zhejiang Provincial Department of Medicine and Health Science and Technology National Natural Science Foundation of China
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
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